3D Bioplotter Research Papers

Immune responses after injury play a critical role in bone regeneration. Initiation of inflammation at early stages of repair triggers tissue formation and remodeling; however, uncontrolled inflammation underlies a catabolic effect on tissues as commonly seen in arthritis where inflammation breaks down tissues and hinders regeneration. Our ultimate goal is to design a novel approach on bone scaffolds for which biodegradable scaffolds are loaded with inflammatory cytokines for local immunomodulation as well as bone regeneration. We employed nanoparticles (NPs) composed of heparin (Hep) and poly-L-lysine (PLL) as cytokine drug carriers adhered on 3D-printed poly(lactic-co-glycolic acid) (PLGA) scaffolds. The entire drug…

In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical…